Search results for "maternal diet"
showing 6 items of 6 documents
Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels…
2016
Journal Article; Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypotha…
Maternal diet shapes the breast milk microbiota composition and diversity: impact of mode of delivery and antibiotic exposure
2020
BACKGROUND: Breast milk is a complex biofluid that provides nutrients and bioactive agents, including bacteria, for the development of the infant gut microbiota. However, the impact of maternal diet and other factors, such as mode of delivery and antibiotic exposure, on the breast milk microbiota has yet to be understood. OBJECTIVES: This study aimed to examine the association between maternal diet and breast milk microbiota and to ascertain the potential role of mode of delivery and antibiotic exposure. METHODS: In a cross-sectional study of the MAMI cohort, breast milk microbiota profiling was assessed in 120 samples from healthy mothers by 16S rRNA gene sequencing. Maternal dietary infor…
INVESTIGATION INTO THE MECHANISMS UNDERLYING THE TRANSGENERATIONAL EFFECTS OF MATERNAL HIGH-FAT DIET-INDUCED DYSBIOSIS ON OFFSPRING BRAIN AND METABOL…
2021
Genetic and environmental factors, and their interactions, contribute to the etiology and pathophysiology of neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD). The clinical heterogeneity and phenotypic variability in patients with NDDs have made identification of causal mechanisms contributing to their onset difficult. Yet, unraveling the underlying causes of NDDs is essential to the development of appropriate preventive/therapeutic strategies. Maternal obesity is considered one of the main nongenetic risk factors for NDDs in progeny. We and others have found that high-fat (HF) obesogenic diets in both humans and animal models induce significant modifications in ma…
Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior
2022
Dysbiosis of the maternal gut microbiome during pregnancy is associated with adverse neurodevelopmental outcomes. We previously showed that maternal high-fat diet (MHFD) in mice induces gut dysbiosis, social dysfunction, and underlying synaptic plasticity deficits in male offspring (F(1)). Here, we reason that, if HFD-mediated changes in maternal gut microbiota drive offspring social deficits, then MHFD-induced dysbiosis in F(1) female MHFD offspring would likewise impair F(2) social behavior. Metataxonomic sequencing reveals reduced microbial richness among female F(1) MHFD offspring. Despite recovery of microbial richness among MHFD-descendant F(2) mice, they display social dysfunction. P…
Consequences of a high sugar/high fat maternal diet on protein expression in young rat salivary glands
2015
Introduction: Early nutrition through maternal diet during pregnancy and breastfeeding was shown to have an impact on obesity in childhood. Experiments on animal models have also indicated alterations regarding taste preferences. In addition, salivary physiology has a documented role in taste preferences and food intake in rodents. The objective of this study was therefore to study the impact of maternal diet on salivary glands’ protein profiles of the offspring.Materials and methods: Female rats received during gestation and lactation either a control (C) or a high fat / high sugar diet (WD for “Western Diet”). 18 offspring rats (9C/9WD) were sacrificed at 25 days of age, i.e. shortly afte…
Impact of a maternal high fat high sucrose diet on progeny's olfactory system
2018
International audience